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P3510

Papaverine hydrochloride

Name: Papaverine hydrochloride
Brand: SIGMA

≥98% (titration by HCL04), powder, cerebral vasodilator

Synonym(s):

6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁NO₄ · HCl

CAS Number:

61-25-6

Molecular Weight:

375.85

NACRES:

NA.77

PubChem Substance ID:

24278152

UNSPSC Code:

41106305

EC Number:

200-502-1

MDL number:

MFCD00012745

Beilstein/REAXYS Number:

3921435

Assay:

≥98%

Form:

powder

Quality level:

100

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Properties

Product Name

Papaverine hydrochloride, powder

assay

≥98%

Quality Level

100

form

powder

color

white

solubility

H₂O: 25 mg/mL

SMILES string

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI key

UOTMYNBWXDUBNX-UHFFFAOYSA-N

Gene Information

human ... PDE4B(5142)

Description

General description

Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.

Application

Papaverine hydrochloride has been used:

in oxygenated Krebs solution for tissue mechanics analysis
as a vasodilator in heparinized horse serum in tissue uptake technique
as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

Biochem/physiol Actions

Papaverine is originally used to resolve male impotence.

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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hcodes

H301

pictograms

GHS06

signalword

Danger

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells

Grundemann D, et al.

British Journal of Pharmacology, 137(6), 910-918 (2002)

Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage

Liu James K and Couldwell William T

Neurocritical Care, 2(2), 124-132 (2005)

Increased glomerular albumin permeability in old spontaneously hypertensive rats

Bakoush O, et al.

Nephrology, Dialysis, and Transplantation, 19(7), 1724-1731 (2004)

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Global Trade Item Number

SKU	GTIN
P3510-100G	04061832899107
P3510-25G	04061834368045
P3510-5G	04061834368052