Key Documents

View All Documentation

C2105

Z-Val-Ala-Asp fluoromethyl ketone

Name: Z-Val-Ala-Asp fluoromethyl ketone
Brand: SIGMA

≥90% (TLC), Caspase-1 inhibitor, powder

Synonym(s):

Z-VAD-FMK, Non-methylated

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₈FN₃O₇

CAS Number:

161401-82-7

Molecular Weight:

453.46

UNSPSC Code:

12352209

PubChem Substance ID:

329774926

NACRES:

NA.77

MDL number:

MFCD03452883

Assay:

≥90% (TLC)

Form:

powder

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Z-Val-Ala-Asp fluoromethyl ketone, powder, ≥90% (TLC)

Quality Level

200

assay

≥90% (TLC)

form

powder

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

InChI key

SUUHZYLYARUNIA-YEWWUXTCSA-N

Description

Biochem/physiol Actions

Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Human granulocytes undergo cell death via autophagy.

Teruyuki Kajiume et al.

Cell death discovery, 4, 111-111 (2018-12-12)

Mature neutrophils must be quickly removed from inflammatory sites to prevent tissue damage. Neutrophil removal is thought to be accomplished primarily through caspase-dependent apoptosis, which involves several genes of mitochondrial origin. However, mature neutrophils show reduced gene transcription and mitochondrial

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter.

Feng Shi et al.

Theranostics, 9(9), 2424-2438 (2019-05-28)

EBV infection is a recognized epigenetic driver of carcinogenesis. We previously showed that EBV could protect cancer cells from TNF-induced necroptosis. This study aims to explore the epigenetic mechanisms allowing cancer cells with EBV infection to escape from RIP3-dependent necroptosis.

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death.

Shuiping Liu et al.

Signal transduction and targeted therapy, 4, 53-53 (2019-12-10)

5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 (PCDH17) gene was frequently methylated and functioned as

View All Related Papers

Global Trade Item Number

SKU	GTIN
C2105-3MG	04061833269602