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H0165

7-Ethyl-10-hydroxycamptothecin

Name: 7-Ethyl-10-hydroxycamptothecin
Brand: SIGMA

powder, ≥98% (HPLC)

Synonym(s):

SN-38

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₀N₂O₅

CAS Number:

86639-52-3

Molecular Weight:

392.40

UNSPSC Code:

12352204

PubChem Substance ID:

329815105

NACRES:

NA.77

MDL number:

MFCD00871873

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Properties

Product Name

7-Ethyl-10-hydroxycamptothecin, ≥98% (HPLC), powder

Quality Level

200

biological source

Artemisia annua

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 1 mg/mL

storage temp.

−20°C

SMILES string

OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O

InChI

1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI key

FJHBVJOVLFPMQE-QFIPXVFZSA-N

Description

Application

7-Ethyl-10-hydroxycamptothecin has been used:

to inhibit enterovirus 71 (EV71) (H) infection
to screen the chemosensitivity of pancreatic adenocarcinoma cells
as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters

Biochem/physiol Actions

Active metabolite of irinotecan. Inhibitor of topoisomerase I.

Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360D,H372

pcodes

P201 - P202 - P260 - P264 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 1

target_organs

Gastro-intestinal system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Global Trade Item Number

SKU	GTIN
H0165-10MG	04061833662748
H0165-50MG	04061833662779