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Merck
CN

H9268

Hexadimethrine bromide

≥94% (titration)

Synonym(s):

1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, Polybrene

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About This Item

CAS Number:
UNSPSC Code:
41106502
NACRES:
NA.26
MDL number:
Technical Service
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Quality Level

assay

≥94% (titration)

storage temp.

2-8°C

SMILES string

BrCCCBr.N(CCCCCCN(C)C)(C)C

InChI

1S/C10H24N2.C3H6Br2/c1-11(2)9-7-5-6-8-10-12(3)4;4-2-1-3-5/h5-10H2,1-4H3;1-3H2

InChI key

KZKAYEGOIJEWQB-UHFFFAOYSA-N

General description

Hexadimethrine bromide is a quaternary ammonium compound which works as a heparin antagonist. It is also involved in the transformation of low molecular weight DNA.

Application

Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.
Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant.


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Protocols

如何利用MISSION shRNA慢病毒颗粒进行慢病毒转导,以实现稳定的长期沉默和表型变化的详细操作步骤。

Lentivirus versions of genome modification technologies support successful CRISPR, RNAi, and ORF experiments.

Detailed procedure for how to perform a lentiviral transduction of MISSION shRNA lentiviral particles to achieve a stable long term silencing and phenotypic change.

View All Protocols

Articles

获取处理慢病毒、优化实验设置、测定慢病毒颗粒滴度以及选择实用转导产品方面的贴士。

Lentiviral vector systems prioritize safety features, with design precautions preventing replication. Good handling practices are essential for use.

Get tips for handling lentiviruses, optimizing experiment setup, titering lentivirus particles, and selecting helpful products for transduction.

View All Articles

Redei GP
Encyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.
Hershko T
The Journal of Biological Chemistry, 281, 31309-31309 (2006)
S Kawai et al.
Molecular and cellular biology, 4(6), 1172-1174 (1984-06-01)
A new procedure for DNA transfection has been developed in a system of chicken embryo fibroblast cells and cloned Rous sarcoma virus DNA by using a polycation reagent as a mediator to adsorb DNA to the cell surface and dimethyl



Global Trade Item Number

SKUGTIN
H9268-5G04061833812235
H9268-100G04061832862576
H9268-10G04061833812198
H9268-50G04061833812228