QuicTPD^™ Amine Optimization Set

This set includes 4 representative partial PROTACs, each provided at 5 micromole quantity.

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The QuicTPD Amine Optimization set is designed to facilitate high throughput synthesis optimization for researchers working with PROTACs.

Two of these PROTACs are tailored to target the CRBN E3 ligase, while the other two are directed towards VHL, incorporating both hydrophobic and hydrophilic linkers. By utilizing this optimization set, customers can explore a variety of reaction conditions—up to 24 or more—before proceeding to the complete screening set. This exploration includes testing different coupling reagents, solvents, and bases, allowing for a comprehensive assessment of the synthesis parameters that influence the efficiency and yield of the desired products.

QuicTPD Amine Screening Set

QuicTPD is a trademark of Merck KGaA, Darmstadt, Germany