description
cholest-5-ene-3β,24(S)-diol
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700061P-1mg), pkg of 1 × 5 mg (700061P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](O)C(C)C)C)(CC3)C)CC=C2C1)C
InChI
1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChI key
IOWMKBFJCNLRTC-XWXSNNQWSA-N
General description
24(S)-羟基胆固醇(24HC)在胆固醇24-羟化酶(CYP46A1)的作用下，由脑树突中的胆固醇合成。它在肝脏中分解代谢为胆汁酸。
Application
24（S）-羟基胆固醇已被用作内标物：
- 在超高效液相色谱-串联质谱（UHPLC-MS/MS）中
- 在液相色谱-串联质谱（LC-MS/MS）中，用于从结直肠肿瘤样本中定量27-羟基胆固醇
- 用于通过液相色谱串联质谱色谱法（LC-MS/MS）定量人血浆甾醇
Biochem/physiol Actions
据报道，24(S)-羟基胆固醇(24HC)在肝脏炎症和纤维化中水平升高。它是一种N-甲基-D-天冬氨酸受体(NMDAR)调节剂。24HC水平是大脑发育以及包括阿尔茨海默′病（AD）和多发性硬化症在内的病理学的潜在指标。胆固醇24羟化酶（CYP46A1）基因多态性导致24HC水平升高和毒性。24HC是细胞凋亡和坏死性凋亡的介质。据报道，肝脏炎症和纤维化中24HC水平升高。
Packaging
5 mL琥珀色玻璃螺旋盖样品瓶(700061P-1mg)
5 mL琥珀色玻璃螺旋盖样品瓶(700061P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
Testing, 12(3) (2017)
Diverse functions of 24 (S)-hydroxycholesterol in the brain
Noguchi N, et al.
Biochemical and Biophysical Research Communications, 446(3), 692-696 (2014)
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
PLoS ONE, 12(3) (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I7256-25G | 04061833858103 |
| I7256-5G | 04061833858110 |
| I7256-1G | 04061833858097 |
| 700061P-1MG | 04061835384709 |
| 700061P-5MG | 04061835384716 |