产品名称
12:0 DG, 1,2-dilauroyl-sn-glycerol, chloroform
assay
>99% (TLC)
form
liquid
packaging
pkg of 2 × 4 mL (800812C-200mg), pkg of 1 × 5 mL (800812C-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 800812C
concentration
2 mg/mL (800812C-10mg), 25 mg/mL (800812C-200mg)
lipid type
neutral lipids
neutral glycerides
shipped in
dry ice
storage temp.
−20°C
InChI
1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1
InChI key
OQQOAWVKVDAJOI-VWLOTQADSA-N
General description
sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.
Application
12:0 DG may be used:
- as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis.
- as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies
- as standard in reverse-phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples
Biochem/physiol Actions
sn-1,2-Diacylglycerols are prime regulators of biological functions, especially in platelets. They also activate protein kinase C. 1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD).
Packaging
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-200mg)
Preparation Note
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
Other Notes
Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
新产品
此项目有
Felicitas S Boretti et al.
Metabolomics : Official journal of the Metabolomic Society, 16(1), 1-1 (2019-12-05)
Food and dietary ingredients have significant effects on metabolism and health. To evaluate whether and how different diets affected the serum lipidomic profile of dogs. Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an
Serum lipidome analysis of healthy beagle dogs receiving different diets
Boretti FS, et al.
Metabolomics, 16(1), 1-1 (2020)
Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm
Callender HL, et al.
Analytical Chemistry, 79(1), 263-272 (2007)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 800812C-200MG | 04061838169563 |