主要文件

查看所有文档

840046X

Avanti

Brain PI(4,5)P2

Name: Brain PI(4,5)P2
Brand: AVANTI

Avanti Research^™ - A Croda Brand

别名:

Brain PI(4,5)P2, L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), chloroform:methanol:water (20:9:1)

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

化学文摘社编号:

383907-42-4

NACRES:

NA.25

UNSPSC Code:

12352211

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (840046X-10mg), pkg of 1 × 1 mL (840046X-1mg), pkg of 1 × 1 mL (840046X-5mg), pkg of 1 × 2.5 mL (840046X-25mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand

concentration

1 mg/mL (840046X-1mg), 10 mg/mL (840046X-10mg), 10 mg/mL (840046X-25mg), 5 mg/mL (840046X-5mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

InChI

1S/C47H85O19P3.3H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)63-39(37-61-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-62-69(59,60)66-45-42(50)43(51)46(64-67(53,54)55)47(44(45)52)65-68(56,57)58;;;/h11,13,17,19,22,24,28,30,39,42-47,50-52H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,59,60)(H2,53,54,55)(H2,56,57,58);3*1H3/b13-11-,19-17-,24-22-,30-28-;;;/t39-,42?,43+,44?,45-,46?,47?;;;/m1.../s1

InChI key

GAIOWTITBYPFJE-JVILRMJCSA-N

说明

General description

Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P₂)/PIP₂ is produced from phosphatidyl inositol monophosphates (PIP).

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Application

Brain PI(4,5)P₂ has been used in the preparation of liposomes for dynamin-catalyzed fission assay and as a constituent in the lipid mixture for dual polarisation interferometry(DPI)

Biochem/physiol Actions

Phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P₂) plays a key role in the early stages of vesicle formation. It functions in the recruitment of endocytic coats by binding to variety of proteins involved in endocytic trafficking. PI(4,5)P₂ is hydrolysed by phospholipase C to yield the signaling molecules diacylglycerol (DAG) and phosphatidyl inositol (3,4,5) triphosphate (PI(3,4,5)P₃). PI(4,5)P₂ is required for the functioning of many ion channels.

Packaging

5 mL Clear Glass Sealed Ampule (840046X-10mg)

5 mL Clear Glass Sealed Ampule (840046X-1mg)

5 mL Clear Glass Sealed Ampule (840046X-25mg)

5 mL Clear Glass Sealed Ampule (840046X-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Still not finding the right product?

Explore all of our products under

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H331,H312,H315,H319,H336,H351,H361d,H370,H372

pcodes

P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

target_organs

Central nervous system, Eyes,Central nervous system, Liver,Kidney

存储类别

3 - Flammable liquids

wgk

WGK 3

法规信息

危险化学品

易制毒化学品（2类）

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Phosphatidylinositol 4, 5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol.

Kinuta M, et al.

Proceedings of the National Academy of Sciences of the USA, 99(5), 2842-2847 (2002)

Phosphoinositides II: The Diverse Biological Functions (2012)

Visualization of HIV-1 Gag Binding to Giant Unilamellar Vesicle (GUV) Membranes.

Olety B, et al.

Journal of Visualized Experiments, 8(113), e54293-e54293 (2016)

查看所有相关文献

全球贸易项目编号

货号	GTIN
840046X-1MG	04061835351718
840046X-5MG	04061835351732
840046X-10MG	04061835351701
840046X-25MG	04061835351725

主要文件

Brain PI(4,5)P2

Avanti Research^™ - A Croda Brand