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Merck
CN

860061P

Avanti

鸡蛋 SM

Avanti Research - A Croda Brand

别名:

16:0 SM;十六烷酰鞘磷脂; N-十六烷酰基-D-赤型鞘氨酰基磷酰胆碱; N-(十六烷酰基)-鞘氨醇-1-磷酸胆碱

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关于此项目

化学文摘社编号:
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
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description

Sphingomyelin (Egg, Chicken)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (860061P-1g), pkg of 1 × 200 mg (860061P-200mg), pkg of 1 × 25 mg (860061P-25mg)

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChI key

RWKUXQNLWDTSLO-GWQJGLRPSA-N

General description

作为细胞膜的主要成分,鞘磷脂在神经细胞(髓鞘)膜和红细胞膜中的浓度特别高。以前认为,它是因鞘氨醇碱基的2-酰胺基、3-羟基和4,5-反式双键介导的分子间相互作用而具有与磷脂酰胆碱功能相似的纯结构作用。但是,现在人们认识到,鞘磷脂对胆固醇具有高亲和力,这两种脂质在液体无序相中紧密堆积成液体有序结构域,形成脂质筏。这些膜微结构域被认为是调节蛋白质定位和相互作用的信号转导平台。但是,鞘磷脂不仅是会影响信号传导的脂质筏成分,它还是神经酰胺和其他鞘脂代谢(包括鞘磷脂循环或鞘脂网络)产物的前体。
鞘磷脂和相关脂质

Application

蛋黄SM可用于制备鞘磷脂(SM)标准溶液。还可用于制备脂质体。

Packaging

20 mL透明玻璃螺旋盖样品瓶(860061P-1g)
5 mL棕色玻璃螺旋盖样品瓶(860061P-200mg)
5 mL棕色玻璃螺旋盖样品瓶(860061P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


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存储类别

11 - Combustible Solids



历史批次信息供参考:

分析证书(COA)

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Morita S, et al.
International Journal of Molecular Sciences, 21(3), 1032-1032 (2020)
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Cardone G, et al.
Journal of Virology, 86(22), 12129-12137 (2012)
Maia Kinnebrew et al.
eLife, 8 (2019-10-29)
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling



全球贸易项目编号

货号GTIN
860061P-200MG04061835316793
860061P-1G04061835316786
860061P-25MG04061835316809