assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860498P-10mg), pkg of 1 × 100 mg (860498P-100mg), pkg of 1 × 25 mg (860498P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
InChI key
OTKJDMGTUTTYMP-ZWKOTPCHSA-N
General description
鞘氨醇（d18:0）是神经酰胺去饱和酶的底物。它是由于补充的甘氨酸向丝氨酸的相互转化而间接合成的。鞘氨醇（d18:0）分解代谢为神经酰胺。
Application
鞘氨醇（d18:0）已用于：
- 作为标准品，利用液相色谱-串联质谱法定量表皮神经酰胺
- 作为培养基补充，检测其对酵母细胞生长的效应
- 制备牛血清白蛋白脂质复合物，研究其对非溶酶体-葡萄糖基神经酰胺酶β2（GBA2）抑制作用的效应
Biochem/physiol Actions
鞘氨醇（d18:0）的水平在1型遗传性感觉神经病细胞中没有改变。在肿瘤缺氧中观察到d18:0的积累。它可用作研究微生物多样性的生物标记物。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860498P-100mg）
5 mL棕色玻璃螺旋盖小瓶（860498P-10mg）
5 mL棕色玻璃螺旋盖小瓶（860498P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Altered sphingolipid metabolism induced by tumor hypoxia-new vistas in glycolipid tumor markers
Yin J, et al.
Febs Letters, 584(9), 1872-1878 (2010)
Sunyoung Hwang et al.
Cell reports, 29(8), 2473-2488 (2019-11-21)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 860498P-10MG | 04061835317387 |
| 860498P-100MG | 04061835317370 |
| 860498P-25MG | 04061835317394 |