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关于此项目
经验公式（希尔记法）:
C35H69NO3
化学文摘社编号:
分子量:
551.93
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860517P-10mg), pkg of 1 × 25 mg (860517P-25mg), pkg of 1 × 5 mg (860517P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C35H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35(39)36-33(32-37)34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h28,30,33-34,37-38H,3-27,29,31-32H2,1-2H3,(H,36,39)/b30-28+/t33-,34+/m0/s1
InChI key
ICWGMOFDULMCFL-QKSCFGQVSA-N
General description
甲酰胺合成可通过以下两种方法进行介导：通过鞘氨醇或鞘氨醇水解的挽救途径；或通过二氢神经酰胺形成的从头途径。在结构上，神经酰胺具有鞘氨醇碱基，即通过酰胺键与脂肪酸连接的长链氨基醇。
Application
C17神经酰胺(d18:1/17:0)已被用于：
- 通过色谱与负离子电喷雾电离串联质谱联用定量测定心肌神经酰胺的内标物，
- 作为串联质谱(MS/MS)的内标物
- 作为鞘磷脂合酶2的底物
Biochem/physiol Actions
神经酰胺在调节各种细胞过程（如衰老和凋亡）中起关键作用。它们直接参与皮肤细胞的增殖和分化并调节皮肤屏障功能。基于神经酰胺的类似物是潜在的抗肿瘤药，被视为抑癌脂质。
Packaging
5 mL 棕色螺旋盖玻璃瓶l (860517P-10mg)
5 mL 棕色螺旋盖玻璃瓶l (860517P-25mg)
5 mL 棕色螺旋盖玻璃瓶l (860517P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Takuya Takeichi et al.
The Journal of clinical investigation, 130(2), 890-903 (2019-11-02)
The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
Longato L, et al.
Oxidative Medicine and Cellular Longevity, 2012 (2012)
André F Nascimento et al.
Life sciences, 88(23-24), 1031-1038 (2011-04-05)
Leptin resistance has been associated with cardiac lipotoxicity; however, whether leptin resistance is a risk factor associated with cardiac lipotoxicity at different time points in diet-induced obesity is unclear. The objective of this study was to evaluate this relationship. Male
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 860517P-10MG | 04061835317608 |
| 860517P-25MG | 04061835317615 |
| 860517P-5MG | 04061835317622 |