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C-121

Carbamazepine-10,11-epoxide solution

Name: Carbamazepine-10,11-epoxide solution
Brand: CERILLIAN

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₂N₂O₂

化学文摘社编号:

36507-30-9

分子量:

252.27

NACRES:

NA.24

PubChem Substance ID:

329774876

UNSPSC Code:

41116107

EC Number:

200-659-6

MDL number:

MFCD00467137

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属性

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O=C(N)N1C2=CC=CC=C2C3C(O3)C4=CC=CC=C14

InChI

1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)

InChI key

ZRWWEEVEIOGMMT-UHFFFAOYSA-N

说明

General description

Carbamazepine-10,11-epoxide is the primary, active metabolite in both urine and serum of carbamazepine, an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder as well as trigeminal neuralgia. Potential toxicity of the epoxide metabolite requires regular therapeutic drug monitoring by LC or LC/MS for patients taking carbamazepine.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

危险化学品

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Instrumental planar chromatographic method for determination of carbamazepine in human serum.

Sigrid Mennickent et al.

Journal of separation science, 32(9), 1454-1458 (2009-03-31)

An instrumental planar chromatographic (HPTLC) method for quantification of carbamazepine in human serum was developed using liquid-liquid extraction with dichloromethane, fluorescence activation with perchloric acid 60%/ethanol/water (1:1:1, v/v) and fluorescence detection. Planar chromatographic separation was performed on precoated silica gel

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.

Ana Fortuna et al.

Analytical and bioanalytical chemistry, 397(4), 1605-1615 (2010-04-20)

For the first time, a simple, selective and accurate high-performance liquid chromatography method with ultraviolet detection was developed and validated to quantify simultaneously three structurally related antiepileptic drugs; carbamazepine, oxcarbazepine, and the recently launched eslicarbazepine acetate and their main metabolites

[Carbamazepine-associated pseudolymphoma].

J F Muñoz-Cerón et al.

Revista de neurologia, 43(11), 700-702 (2006-11-30)

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全球贸易项目编号

货号	GTIN
76170-5G	04061832918501
C-121-1ML	04061833449714
Z503681-1EA	04061832265490

主要文件

Carbamazepine-10,11-epoxide solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®