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A8456

4-（2-氨乙基）苯磺酰氟 盐酸盐

≥97.0% (HPLC)

别名:

AEBSF

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关于此项目

经验公式（希尔记法）:
C8H10FNO2S · HCl
化学文摘社编号:
30827-99-7
分子量:
239.69
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
24278240
MDL number:
MFCD00132962
Beilstein/REAXYS Number:
7604627
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biological source

synthetic (organic)

Quality Level

300

assay

≥97.0% (HPLC)

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

General description

在pH 7以下可低温稳定保存6个月。如需要pH大于7，务必在临用前再调节pH。

Application

4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）已用作：
  • 血浆样品中的蛋白酶抑制剂，以防止酰基化胃饥饿素（AG）降解
  • SVSP抑制或AEBSF测定中的蛇毒丝氨酸蛋白酶（SVSP）抑制剂，以测定SVSP的参与度对纤维蛋白原凝血活性的影响
  • NP-40裂解缓冲液的组分，以重悬细胞微球制备细胞裂解物

建议使用浓度为 0.1 至 1mM。

Biochem/physiol Actions

4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）是一种不可逆丝氨酸蛋白酶抑制剂。抑制常数与苯甲磺酰氟（PMSF）和二异丙基氟磷酸（DFP）相似。 经证实，AEBSF可抑制胰蛋白酶、胰凝乳蛋白酶、纤溶酶、激肽释放酶和凝血酶。作为PMSF和DFP的替代品，AEBSF具有较低的毒性，并提高了在水中的溶解性和水溶液中的稳定性。AEBSF可用于浓度高达0.25 mM的细胞培养。
AEBSF可抑制乙酰胆碱酯酶（AChE）。

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1A

存储类别

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
019M4008V
026M4102V
13150402
13170109
069M4058V

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全球贸易项目编号

货号GTIN
A8456-100MG04061833391631
A8456-25MG04061833391648
A8456-500MG04061833391655