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D0700000

地塞米松

Name: 地塞米松
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

(11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮, 9α-氟-16α-甲基泼尼松龙, 泼尼松龙F

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₉FO₅

化学文摘社编号:

50-02-2

分子量:

392.46

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329798628

EC Number:

200-003-9

Beilstein/REAXYS Number:

2066651

MDL number:

MFCD00064136

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属性

biological source

synthetic

grade

pharmaceutical primary standard

agency

API family

dexamethasone

packaging

pkg of 50 mg

manufacturer/tradename

EDQM

storage condition

protect from light

mp

262-264 °C (lit.)

solubility

water: <0.1 g/L

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... NR3C1(2908)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone EP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

Biochem/physiol Actions

糖皮质激素抗炎剂

糖皮质激素抗炎剂。调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Dexamethasone

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 4961-4963 (2021)

Spectrophotometric resolution of ternary mixtures of Dexamethasone, Polymyxin B and Trimethoprim in synthetic and pharmaceutical formulations

Gallego JML and Arroyo JP

Analytica Chimica Acta, 437(2), 247-257 (2001)

Determination of prednisolone, dexamethasone and hydrocortisone in pharmaceutical formulations and biological fluid samples by voltammetric techniques using b-cyclodextrin modified carbon paste electrode

Balaji K, et al.

African Journal of Pharmacy and Pharmacology, 2(8), 157-166 (2008)

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全球贸易项目编号

货号	GTIN
D0700000	04061833558003