Quality Level
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. C0100000, traceable to USP 1085003
API family
dimenhydrinate, caffeine, pentoxifylline
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
234-236.5 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
CN1C(=O)N(C)c2ncn(C)c2C1=O
InChI
1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
InChI key
RYYVLZVUVIJVGH-UHFFFAOYSA-N
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
General description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.
Application
Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
Srdjenovic B, et al.
Journal of Chromatographic Science, 46(2), 144-149 (2008)
Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode.
Lourenc?o BC
Talanta, 78(3), 748-752 (2009)
Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution.
Mart?n MJ, et al.
Talanta, 49(2), 453-459 (1999)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PHR1009-1G | 04061835236855 |
