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PHR1107

L-谷氨酸

Name: <SC>L</SC>-谷氨酸
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(S)-2-氨基戊二酸, Glu

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关于此项目

线性分子式:

HO₂CCH₂CH₂CH(NH₂)CO₂H

化学文摘社编号:

56-86-0

分子量:

147.13

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823129

EC Number:

200-293-7

Beilstein/REAXYS Number:

1723801

MDL number:

MFCD00002634

eCl@ss:

32160406

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. G0355000, traceable to USP 1294976

API family

glutamic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

205 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

说明

General description

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

Application

L-谷氨酸可用作药物参考标准品，用于通过离子色谱技术测定药物制剂中的分析物。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

Biochem/physiol Actions

一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

本有证标准物质 (CRM) 按照 ISO 17034 和 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息，请参见检验报告。

要查看该材料的检验报告示例，请在下面的插槽中输入 LRAA7158。这只是一个示例证书，可能不是您收到的批次。

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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection

Megoulas NC and Koupparis MA

Journal of Chromatography A, 1026(1-2), 167-174 (2004)

Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers.

G Alfredsson et al.

Biological psychiatry, 23(7), 689-697 (1988-04-01)

The concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 4-hydroxy-3-methoxyphenylglycol (HMPG), and glutamate were determined in cerebrospinal fluid (CSF) and serum in 10 healthy volunteers. The monoamine metabolites were measured by mass fragmentography and the glutamate by high-performance liquid chromatography.

Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

Luigi F Agnati et al.

Pharmacological reviews, 55(3), 509-550 (2003-07-19)

The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers. The discovery of GABAB heterodimers started this field rapidly followed by

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全球贸易项目编号

货号	GTIN
PHR1107-1G	04061835233045