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PHR1325

土霉素盐酸盐 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Oxytetracycline hydrochloride, 5-Hydroxytetracycline hydrochloride

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关于此项目

经验公式（希尔记法）:
C22H24N2O9 · HCl
化学文摘社编号:
2058-46-0
分子量:
496.89
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823310
EC Number:
218-161-2
Beilstein/REAXYS Number:
3853107
MDL number:
MFCD00135815
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. O0500000, traceable to USP 1491015

API family

oxytetracycline

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1

InChI key

UBDNTYUBJLXUNN-IFLJXUKPSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Oxytetracycline is a broad-spectrum antibiotic drug widely employed in veterinary applications, particularly for the management of infections in pig productions. It acts by inhibiting the protein synthesis in gram-positive and gram-negative bacteria.

Application

Oxytetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0828 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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商品

Antibiotic Analysis Tetracyclines Sulfonamides Quinolones

LC-MS/MS-based determination of 19 sulfonamides, 13 quinolones, and 3 tetracycline drug residues in pork meat samples using Supel™ Swift HLB for extraction.

Simultaneous determination of sulfathiazole and oxytetracycline in honey by derivative spectrophotometry
Salinas F, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 43(3), 244-252 (1991)
Determination of oxytetracycline and doxycycline in pharmaceutical compounds, urine and honey by derivative spectrophotometry
Salinas F, et al.
Analyst, 114(9), 1141-1145 (1989)
Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems
Loke ML, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 783(1), 11-23 (2003)
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全球贸易项目编号

货号GTIN
PHR1325-500MG04061835233625