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PHR1376

氯雷他定

Name: 氯雷他定
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氯雷他定, 4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₃N₂O₂Cl

化学文摘社编号:

79794-75-5

分子量:

382.88

NACRES:

NA.24

PubChem Substance ID:

329823353

UNSPSC Code:

41116107

MDL number:

MFCD00672869

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1370270, traceable to Ph. Eur. Y0000688

API family

loratadine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

说明

General description

氯雷他定是没有镇静作用的H1抗组胺类药物，广泛用于过敏治疗。

Application

氯雷他定(Loratadine)可用作药物参考标准品，用于通过分光光度技术测定药物制剂中的分析物。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

Biochem/physiol Actions

非镇静组胺H₁-受体拮抗剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

想要查看本品的检验报告(CoA)示例，请在下框中输入LRAC3785。这只是一个示例证书，可能与您收到的批次不符。

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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商品

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

Determination of loratadine in pharmaceuticals by a spectrophotometric method

Pavalanche G, et al.

Ovidius University Annals of Chemistry, 26(1), 27-31 (2015)

Loratadine in the treatment of urticaria.

E W Monroe

Clinical therapeutics, 19(2), 232-242 (1997-03-01)

Urticaria is a common skin disease, which in its chronic form, is a very disturbing condition. Because histamine is the best-documented chemical mediator of urticaria, histamine-antagonists are the mainstay of therapy. First-generation antihistamines are limited by their tendency to produce

Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders.

M Haria et al.

Drugs, 48(4), 617-637 (1994-10-01)

Loratadine is a long-acting antihistamine agent, exhibiting partial selectivity for peripheral histamine H1-receptors. To date, loratadine has been evaluated in allergic rhinitis, urticaria and, to a limited extent, in asthma. In several large controlled comparative clinical studies, loratadine was superior

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全球贸易项目编号

货号	GTIN
PHR1376-1G	04061835233854