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Merck
CN

Y0001298

苯丁酸氮芥

European Pharmacopoeia (EP) Reference Standard

别名:

苯丁酸氮芥, 4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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关于此项目

经验公式(希尔记法):
C14H19Cl2NO2
化学文摘社编号:
分子量:
304.21
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
999011
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grade

pharmaceutical primary standard

API family

chlorambucil

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorambucil for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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[Renal amyloidosis in rheumatoid polyarthritis stabilized for 13 years with chlorambucil].
Y Maugars et al.
Revue du rhumatisme et des maladies osteo-articulaires, 57(1), 41-44 (1990-01-01)
R G Palmer et al.
Cancer treatment reviews, 11(2), 121-129 (1984-06-01)
There is a high incidence of acute myeloid leukaemia in patients who have been treated with chlorambucil. This appears at least in part to be directly due to the drug itself and cannot be attributed to the disease processes for
R Torricelli et al.
Schweizerische medizinische Wochenschrift, 125(40), 1870-1873 (1995-10-07)
A 63-year-old man developed a mild hemorrhagic diathesis which led to the diagnosis of chronic lymphatic leukemia. Treatment with prednisone and chlorambucil was initiated. During the first 10 day-cycle (10 mg chlorambucil and 100 mg prednisone) no side effects were



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货号GTIN
Y000129804061833807002