主要文件

查看所有文档

A0835

N-Acetyl-Asp-Glu-Val-Asp-al

Name: N-Acetyl-Asp-Glu-Val-Asp-al
Brand: SIGMA

≥95%, powder

别名:

Ac-DEVD-CHO

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₀H₃₀N₄O₁₁

化学文摘社编号:

169332-60-9

分子量:

502.47

NACRES:

NA.32

PubChem Substance ID:

24890193

UNSPSC Code:

12352209

MDL number:

MFCD00671412

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

biological source

synthetic

assay

≥95%

form

powder

color

white

solubility

H₂O: 1 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI key

UMBVAPCONCILTL-UHFFFAOYSA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

说明

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 是一种具有N端乙酰化和C端醛共轭的四肽。

Application

N-Acetyl-Asp-Glu-Val-Asp-al已在肌肉样品、平滑肌细胞和Jurkat T细胞中被用作半胱氨酸蛋白酶抑制剂。

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 可通过其半胱氨酸蛋白酶抑制剂的功能性有助于顿抑心肌的恢复。

IL-1β的可逆性抑制剂；转化酶（ICE）；通过凋亡蛋白（caspase 3）抑制聚（ADP-核糖）聚合酶的切割。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

In- and ex-vivo molecular imaging of apoptosis to assess sensitivity of non-small cell lung cancer to EGFR inhibitors using probe-based confocal laser endomicroscopy.

Florian Guisier et al.

PloS one, 12(7), e0180576-e0180576 (2017-07-04)

Prediction of treatment outcome of non-small cell lung cancer (NSCLC) with EGFR inhibitors on the basis of the genetic analysis of the tumor can be incorrect in case of rare or complex mutations, bypass molecular activation pathways, or pharmacodynamic variations.

The steroid hormone 20-hydroxyecdysone promotes switching from autophagy to apoptosis by increasing intracellular calcium levels.

Yong-Bo Li et al.

Insect biochemistry and molecular biology, 79, 73-86 (2016-10-26)

Autophagy regulates cell survival (or cell death in several cases), whereas apoptosis regulates cell death. However, the relationship between autophagy and apoptosis and the regulative mechanism is unclear. We report that steroid hormone 20-hydroxyecdysone (20E) promotes switching from autophagy to

Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells.

Carles Solà-Riera et al.

Scientific reports, 9(1), 834-834 (2019-01-31)

Orthohantaviruses, previously known as hantaviruses, are zoonotic viruses that can cause hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) in humans. The HPS-causing Andes virus (ANDV) and the HFRS-causing Hantaan virus (HTNV) have anti-apoptotic effects. To investigate

查看所有相关文献

全球贸易项目编号

货号	GTIN
A0835-1MG	04061833334508
A0835-5MG	04061833267066