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A4403

L -抗坏血酸

Name: <SC>L </SC>-抗坏血酸
Brand: SIGMA

powder, suitable for cell culture, γ-irradiated

别名:

维他命C, 抗坏血病因子, 维生素C

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关于此项目

经验公式（希尔记法）:

C₆H₈O₆

化学文摘社编号:

50-81-7

分子量:

176.12

UNSPSC Code:

12352207

NACRES:

NA.75

PubChem Substance ID:

24890857

EC Number:

200-066-2

Beilstein/REAXYS Number:

84272

MDL number:

MFCD00064328

Form:

powder

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属性

biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

form

powder

mol wt

M_w 176.12 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

solubility

H₂O: 10 mg/mL

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Gene Information

human ... SLC23A2(9962)

说明

General description

L-抗坏血酸是一种不饱和γ-内酯环，含有与羰基相连的烯二醇构型(-COH =COH)。

Application

用于细胞培养，作为抗氧化剂和再生生育酚。
L-抗坏血酸已应用于：

用于细胞生长的成骨补充剂
作为分化介质的一个组成部分
在WS-MSCs(沃纳综合征-间充质干细胞)中研究抗坏血酸对衰老缺陷的修复作用

Biochem/physiol Actions

L-抗坏血酸主要具有抗氧化性能。它保护植物免受氧化应激，保护哺乳动物免受与氧化应激相关的疾病。L-抗坏血酸主要对羟基自由基、超氧化物和单线态氧起保护作用。此外，它还还原膜连接的抗氧化剂α-生育酚(氧化形式)。L-抗坏血酸增强内皮依赖性血管舒张在各种疾病，包括糖尿病，冠状动脉疾病，高血压和慢性心力衰竭。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

诱导多能干细胞重编程实验方案

产生人诱导多能干细胞（iPSC）的干细胞重编程实验方案，包括基于病毒和非病毒RNA的方法。

Guide: Expansion & Differentiation of Human Mesenchymal

TrueGel3D^® Hydrogel Plate protocol guides high-throughput culture of human adipose MSCs for screening applications.

Induced Pluripotent Stem Cell Reprogramming Protocols

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

商品

3D类器官培养：用于开发及疾病研究的新体外模型

可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。

3D Organoid Culture: New In Vitro Models of Development and Disease

Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

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Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells.

Xi Wang et al.

Archives of oral biology, 57(9), 1231-1240 (2012-03-30)

This study focused on the characterization of stem cells from human exfoliated deciduous teeth (SHED) in comparison with dental pulp stem cells (DPSCs) to certify SHED as a key element in tissue engineering. In the present study, SHED and DPSCs

L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells.

R Heller et al.

The Journal of biological chemistry, 274(12), 8254-8260 (1999-03-13)

Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free oxygen radicals. The present study in human endothelial cells

Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing.

Davey MW

Journal of the Science of Food and Agriculture, 80, 825-860 (2000)

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全球贸易项目编号

货号	GTIN
A4403-100MG	04061833374429