C0605
Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone
≥90% (HPLC)
别名:
Z-DEVD-FMK
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关于此项目
经验公式（希尔记法）:
C30H41N4O12F
化学文摘社编号:
分子量:
668.66
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
assay
≥90% (HPLC)
form
powder
color
off-white
solubility
DMSO: ≥20 mg/mL, clear
shipped in
dry ice
storage temp.
−20°C
SMILES string
COC(=O)CC[C@H](NC(=O)[C@H](CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
InChI
1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChI key
GBJVAVGBSGRRKN-JYEBCORGSA-N
Biochem/physiol Actions
A cell-permeable inhibitor of caspase 3, 6, 7, 8, 10, which exhibits competitive and irreversible inhibition.
Features and Benefits
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Karianne Risberg et al.
PloS one, 6(9), e24012-e24012 (2011-09-15)
In cancer, combinations of drugs targeting different cellular functions is well accepted to improve tumor control. We studied the effects of a Pseudomonas exotoxin A (PE)-based immunotoxin, the 9.2.27PE, and the BH-3 mimetic compound ABT-737 in a panel of melanoma
Xiao Feng et al.
Cancer letters, 385, 12-20 (2016-11-09)
Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence
Jin Hwa Cho et al.
BMB reports, 46(12), 588-593 (2013-11-08)
Apoptosis, programmed cell death, is a process involved in the development and maintenance of cell homeostasis in multicellular organisms. It is typically accompanied by the activation of a class of cysteine proteases called caspases. Apoptotic caspases are classified into the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C0605-3MG | 04061833269367 |