产品名称
2′-脱氧腺苷5′-三磷酸 钠盐 溶液, 100 mM, pH 7
assay
≥99%
Quality Level
form
liquid
concentration
100 mM
color
colorless
pH
7
foreign activity
DNase, RNase, none detected
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na+].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)O3
InChI
1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/q;+1/p-1/t5-,6+,7+;/m0./s1
InChI key
YJWCICGGRLOGEH-VWZUFWLJSA-M
General description
2′-脱氧腺苷5′-三磷酸（dATP）由脱氧核糖上的一个碱基和糖上与一个由三个磷酸残基组成的链相结合的糖上的5′-羟基组成。细胞利用dATP通过DNA聚合酶合成DNA。
Application
2′-脱氧腺苷5′-三磷酸钠盐水已用于通过末端脱氧核苷酸转移酶dUTP缺口末端标记（TUNEL）技术检测凋亡细胞。还用于促进凋亡蛋白酶活化因子-1(Apaf-1)寡聚化形成名为凋亡体或Apaf-1 procaspase-9凋亡体复合物的七聚体大复合体，并用于研究其基于蛋白降解的分子计时器功能。
2′-脱氧腺苷5′-三磷酸盐钠盐可用于DNA合成反应，如PCR、DNA测序和分子克隆技术。
Other Notes
T4 DNA连接酶以溶于20 mM Tris-HCl（pH 7.5），50 mM KCl，1 mM DTT和50%（v/v）甘油的溶液形式提供。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach
Jager W, et al.
Testing, 8(3), e59536-e59536 (2013)
Christina M Zimanyi et al.
Structure (London, England : 1993), 20(8), 1374-1383 (2012-06-26)
Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits
Kousuke Sato et al.
Chembiochem : a European journal of chemical biology, 12(15), 2341-2346 (2011-09-03)
We herein describe the synthesis of fluorescent 5-(5,6-dimethoxybenzothiazol-2-yl)-2'-deoxyuridine 5'-triphosphate (d(bt)UTP) and primer extension reactions using d(bt)UTP. We also carried out primer extension reactions using the (bt)U template. B family DNA polymerases, such as KOD, Deep Vent (exo-), and 9°N(m) DNA
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D4788-.1MMO | 04061833451014 |
| D4788-25UMO | 04061833585696 |