E7280
Elafin
recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),
别名:
Elastase-specific inhibitor, skin-derived antileukoprotease
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
产品名称
Elafin 人, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
recombinant
expressed in Saccharomyces cerevisiae
Quality Level
assay
>90% (by MS, HPLC and SDS-PAGE)
form
powder
potency
1.7 x 10-10 M Ki (human leukocyte elastase), 4.2 x 10-10 M Ki (human proteinase 3)
mol wt
~6 kDa
UniProt accession no.
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
enzyme | inhibits
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PI3(5266)
General description
Chemical structure: peptide
Biochem/physiol Actions
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
商品
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E7280-100UG | 04061833605035 |