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EPS002

MS-275

Name: MS-275
Brand: SIGMA

A HDAC1 and HDAC3 inhibitor

别名:

MS-275 (Entinostat, SNDX-275), 3-吡啶基甲基[[4-[[(2-氨基苯基)氨基]羰基]苯基]甲基]氨基甲酸酯, N-(2-氨基苯基)-4-[N-(吡啶-3-甲氧基羰基)氨甲基]苯甲酰胺

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₀N₄O₃

化学文摘社编号:

209783-80-2

分子量:

376.41

NACRES:

NA.41

PubChem Substance ID:

329799578

UNSPSC Code:

12352200

MDL number:

MFCD03453552

Assay:

≥99%

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属性

assay

≥99%

solubility

DMSO: 38 mg/mL

storage temp.

−20°C

SMILES string

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChI key

INVTYAOGFAGBOE-UHFFFAOYSA-N

Gene Information

human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

说明

General description

优先于HDAC3（IC₅₀=8 μM）抑制HDAC1（IC₅₀ = 300nM）。对HDAC8（IC₅₀>100 μM）无抑制活性。

Application

MS-275已被用作组蛋白脱乙酰酶-1抑制剂。

Biochem/physiol Actions

HDAC抑制剂，抗增殖。

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H360

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

7E06L15900

4K011590

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全球贸易项目编号

货号	GTIN
EPS002-1MG	04061833609569
EPS002-5MG	04061833609576