H1759
(+)-生物素N-羟基琥珀酰亚胺酯
≥98% (HPLC), powder
别名:
(+)-生物素N-琥珀酰亚胺酯, d-生物素NHS酯, BNHS, N-琥珀酰亚胺基D-生物素, N-羟基琥珀酰亚胺生物素, NHS-生物素, 生物素-N-羟基琥珀酰亚胺
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关于此项目
经验公式（希尔记法）:
C14H19N3O5S
化学文摘社编号:
分子量:
341.38
UNSPSC Code:
12352203
NACRES:
NA.46
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4720781
Quality Level
assay
≥98% (HPLC)
form
powder
reaction suitability
reaction type: Biotinylations
color
white to off-white
mp
212 °C
solubility
DMF: ≤50 mg/mL (Stable for at least one month in dry DMF), DMSO: soluble
storage temp.
−20°C
SMILES string
[H][C@]12CS[C@@H](CCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2
InChI
1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1
InChI key
YMXHPSHLTSZXKH-RVBZMBCESA-N
Application
(+)-生物素NHS酯，或称(+)-生物素 N-羟基琥珀酰亚胺酯，已用于：
- 生物素化Hyb 246-4，用于表面活性剂蛋白 D 酶联免疫吸附试验（SP-D ELISA）
- 生物素化蛋白质以形成预成型络合物
- 标记和修饰单克隆抗微纤维相关蛋白 4 (MFAP4) (HG-HYB 7-18)，以结合到alphaLISA 链霉亲和素涂层供体珠
Biochem/physiol Actions
N-羟基琥珀酰亚胺酯（NHS）生物素修饰有助于目标赖氨酸残基在ε-氨基上的生物素化，并识别表面赖氨酸残基。它被用作识别蛋白质与几种生物分子相互作用的工具，如蛋白质-多糖相互作用、蛋白质-蛋白质相互作用、蛋白质-核酸相互作用和蛋白质-配体相互作用。NHS-生物素可用于蛋白和肽的生物素化。它通常在6.5-8.5的pH范围内通常偶联至伯胺。
Disclaimer
除非在我们的产品目录或产品随附的其他公司文档中另有说明，我们的产品仅供研究使用并不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途、任何类型的食用或应用于人或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Troels R Kjaer et al.
Infection and immunity, 81(2), 452-459 (2012-11-28)
The three human ficolins (H-, L-, and M-ficolins) and mannan-binding lectin are pattern recognition molecules of the innate immune system mediating activation of the lectin pathway of the complement system. These four human proteins bind to some microorganisms and may
Cecilie Bo Hansen et al.
Journal of immunology (Baltimore, Md. : 1950), 195(8), 3596-3604 (2015-09-16)
C1 inhibitor (C1-INH) is known to form complexes with the lectin complement pathway serine proteases MASP-1 and MASP-2. Deficiency of C1-INH is associated with hereditary angioedema (HAE), an autosomal inherited disease characterized by swelling attacks caused by elevated levels of
Ying-Xia Tan et al.
Glycobiology, 28(5), 269-275 (2018-02-23)
Heparanase, an endo-glucuronidase that specifically cleaves heparan sulfate (HS), is upregulated in several pathological conditions. In this study, we aimed to find a correlation of heparanase expression and platelets production. In the transgenic mice overexpressing human heparanase (Hpa-tg), hematological analysis
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H1759-100MG | 04061833697740 |
| H1759-5MG | 04061833699836 |
| H1759-1G | 04061833699744 |
| H1759-250MG | 04061833262207 |
| H1759-25MG | 04061833699768 |