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H5784

(2-羟丙基)-β-环糊精 溶液

别名:

羟丙基-β-环糊精

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关于此项目

线性分子式:
(C6H9O5)7 · (C3H7O)4.5
NACRES:
NA.77
PubChem Substance ID:
24895710
UNSPSC Code:
12352201
MDL number:
MFCD00069372
Form:
solution (clear, colorless)
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biological source

synthetic (organic)

Quality Level

200

form

solution (clear, colorless)

mol wt

~1396 Da

concentration

45 % (w/v) in H2O

storage temp.

2-8°C

SMILES string

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3

InChI key

DCQLZTSRKLWEAB-UHFFFAOYSA-N

General description

2-羟丙基-β-环糊精是通过对环低聚糖β-环糊精进行化学修饰而得到的。它被用作疫苗的潜在佐剂。水溶液缓冲液中的2-羟丙基-β-环糊精可增加药物的溶解度。它对小鼠和兔子无毒。药物/环糊精配合物的形成是一个快速可逆的反应，配合物以溶液和结晶两种状态存在。许多这类络合物的溶液可被冻干以产生可压缩成片剂的易溶性粉末。

Application

(2-羟丙基)-β-环糊精溶液已用于：
  • 制备Cdc42活性特异性抑制剂（CASIN）药物新鲜溶液，用于C57BL/6小鼠表观遗传衰老特征分析
  • 制备重塑素和重塑素荧光剂溶液，用于评估重塑素在小鼠体内的毒性
  • 作为柠檬酸钠溶液的组分，用于复溶卡非佐米（PR-171）

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCL4807
SLCJ2845
SLCJ2842
SLCJ2844
SLCJ2466

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货号GTIN
H5784-10ML04061833799772