I6125
碘乙酰胺
≥99% (NMR), crystalline
别名:
α-Iodoacetamide, 2-Iodoacetamide
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关于此项目
线性分子式:
ICH2CONH2
化学文摘社编号:
分子量:
184.96
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
205-630-1
Beilstein/REAXYS Number:
1739080
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥99% (NMR)
form
crystalline
mp
92-95 °C (lit.)
solubility
H2O: soluble 0.5 M, clear, colorless
storage temp.
2-8°C
SMILES string
NC(=O)CI
InChI
1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
InChI key
PGLTVOMIXTUURA-UHFFFAOYSA-N
Application
- 一种基于使用碘乙酰胺和丙烯酰胺对半胱氨酸进行差异烷基化的蛋白质质谱定量策略。：本研究提出了一种新的质谱方法，通过用碘乙酰胺和丙烯酰胺对半胱氨酸进行差异烷基化来定量蛋白质，从而提高复杂样品中蛋白质定量的准确性。（Virág et al., 2024）。
- 海带多糖通过调节5-HT(3)受体和肠道微生物群改善碘乙酰胺诱导的功能性消化不良。：研究表明，海带多糖可以通过调节5-HT(3)受体和改变肠道微生物群组成来减轻碘乙酰胺诱导的功能性消化不良，从而提供潜在的治疗效果。（Liu et al., 2024）。
- 黑色素瘤细胞的氧化还原蛋白质组学：优化方案。：本文描述了一种使用碘乙酰胺优化的氧化还原蛋白质组学方案，该方案有助于识别黑色素瘤细胞中的氧化还原敏感蛋白，有助于了解癌症中的氧化还原调节。（Cunha et al., 2024）。
- 通过基于竞争活性的蛋白质分析策略探索顺铂在HeLa细胞中的分子靶点。：本研究使用碘乙酰胺进行基于竞争活性的蛋白质分析，确定了顺铂在HeLa细胞中的分子靶点，进一步阐释了药物机制。（Chen et al., 2024）。
- 4-硫尿苷向胞苷碱转化反应的进展和比较。：本研究比较了涉及4-硫尿苷和胞苷的碱基转化反应，其中碘乙酰胺在反应机制中起着至关重要的作用，为核苷酸化学的进步添砖加瓦。（Ohashi et al., 2024）。
Biochem/physiol Actions
碘乙酰胺在肽测序中胱氨酸残基的烷基化试剂。它是活性位点上含有胱氨酸的酶的的一种不可逆抑制剂。它与组氨酸残基的反应速度要慢得多，但这种活性是核糖核酸酶抑制的原因。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I6125-10G | 04061835545803 |
| I6125-1KG | 04061826718421 |
| I6125-100G | 04061835545797 |
| I6125-25G | 04061835545810 |
| I6125-5G | 04061835545827 |