L0649
亮肽素 盐酸盐
powder, ≥70% (HPLC)
别名:
Acetyl-Leu-Leu-Arg-al 盐酸盐
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关于此项目
经验公式（希尔记法）:
C20H38N6O4 · HCl
化学文摘社编号:
分子量:
463.01
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
亮肽素 盐酸盐, microbial, ≥70% (HPLC)
biological source
microbial
Quality Level
assay
≥70% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to yellow
storage temp.
−20°C
SMILES string
Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
InChI
1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
InChI key
OQQYPQNFLLAILR-UHFFFAOYSA-N
Biochem/physiol Actions
丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶 B。不抑制胃蛋白酶、组织蛋白酶 A 和 D、凝血酶或 α-糜蛋白酶。有效浓度 10-100 μM。
丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶 B。不抑制胃蛋白酶、组织蛋白酶 A 和 D、凝血酶或 α-糜蛋白酶。有效浓度 10-100 μM。已有许多研究使用亮肽素预防由声过度刺激或耳毒性抗生素庆大霉素引起的听力丧失。（耳蜗毛细胞的丢失被认为是由钙蛋白酶介导的。）
Analysis Note
Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L0649-100MG | 04061833262986 |
| L0649-25MG | 04061833948910 |
| L0649-5MG | 04061833948927 |