M7316
单胺氧化酶A 人
recombinant, expressed in baculovirus infected BTI insect cells
别名:
MAO-A, MAOA
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关于此项目
Recombinant:
expressed in baculovirus infected BTI insect cells
recombinant
expressed in baculovirus infected BTI insect cells
Quality Level
form
liquid
packaging
vial of ~2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAOA(4128)
General description
单胺氧化酶A含有8α-S-半胱氨酰-FAD的结合位点。
单胺氧化酶可对中枢神经系统和外周组织中的生物胺进行代谢。
Application
单胺氧化酶A已被用于评估具有单胺氧化酶A酶活性不足的大批男性的异常行为。 它也被用于研究调查吸烟与抑制MAOA之间的关联。
Biochem/physiol Actions
MAO是一种线粒体膜蛋白。 这些酶负责催化内生和异生胺的氧化脱氨。 每种同工酶的底物特异性不同。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
商品
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Dale E Edmondson et al.
Neurotoxicology, 25(1-2), 63-72 (2003-12-31)
The structural details of the interactions of the covalent 8alpha-S-cysteinyl-FAD with the protein moiety in monoamine oxidase B (MAO B) based on the MAO B crystal structure are described. The dinucleotide is bound to the protein in an extended conformation
J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M7316-1VL | 04061834061915 |
| M7316-5X1VL | 04061834061922 |