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M9771

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin

Name: N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin
Brand: SIGMA

elastase substrate

别名:

MeOSuc-AAPV-AMC

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关于此项目

经验公式（希尔记法）:

C₃₁H₄₁N₅O₉

化学文摘社编号:

72252-90-5

分子量:

627.69

NACRES:

NA.32

PubChem Substance ID:

24897367

UNSPSC Code:

12352204

MDL number:

MFCD00077135

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属性

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)

InChI key

CMEUDEVBFFPSEI-UHFFFAOYSA-N

说明

General description

Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.

Application

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay using bone marrow lysates and pancreatic lysates.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.

M J Castillo et al.

Analytical biochemistry, 99(1), 53-64 (1979-10-15)

Glutamine Therapy Reduces Inflammation and Extracellular Trap Release in Experimental Acute Respiratory Distress Syndrome of Pulmonary Origin.

Gisele Pena de Oliveira et al.

Nutrients, 11(4) (2019-04-25)

The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS). Glutamine (Gln) decreases lung inflammation in experimental ARDS, but its impact on the formation of extracellular traps (ETs) in the lung is unknown.

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.

Jonas Hahn et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1401-1414 (2018-08-22)

Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or

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全球贸易项目编号

货号	GTIN
M9771-50MG	04061832909479
M9771-5MG	04061832909486