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Merck
CN

O2751

草氨酸钠

≥98%

别名:

氨基氧乙酸 钠盐, 草氨酸 钠盐, 草酸单酰胺 钠盐

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关于此项目

线性分子式:
NH2COCOONa
化学文摘社编号:
分子量:
111.03
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
209-290-5
Beilstein/REAXYS Number:
6538153
MDL number:
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biological source

synthetic (organic)

Quality Level

assay

≥98%

form

powder

mp

300 °C

solubility

water: 50 mg/mL, clear, colorless

SMILES string

[Na+].NC(=O)C([O-])=O

InChI

1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1

InChI key

RQVZIJIQDCGIKI-UHFFFAOYSA-M

Application

草案酸钠用于:
  • 流动注射分析变量
  • 体外血管新生实验
  • 确认硬脂酸在乳糖脱氢酶介导乳糖生产中的刺激作用

Biochem/physiol Actions

草氨酸钠影响脂肪酸代谢。可用于治疗糖尿病。
丙酮酸结构类似物,抑制L(+)-乳酸脱氢酶,使得整个糖异生途径脱轨。乳酸脱氢酶结合研究;抑制线粒体丙酮酸代谢机制


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

本页面介绍了一篇有关瓦博格效应的文章,以及其如何能够在正常氧气水平下,增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明,癌细胞显示出对糖酵解的依赖性增加,以满足他们的能量需求,无论是否有充足的氧气存在。

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.


Joshua Marshall Thornburg et al.
Breast cancer research : BCR, 10(5), R84-R84 (2008-10-17)
Glycolysis is increased in breast adenocarcinoma cells relative to adjacent normal cells in order to produce the ATP and anabolic precursors required for survival, growth and invasion. Glycolysis also serves as a key source of the reduced form of cytoplasmic
Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate
Muller Werner EG, et al.
The Biochemical Journal, 475(20), 3255-3273 (2018)
Stefania Arioli et al.
Frontiers in microbiology, 9, 2719-2719 (2018-11-27)
Streptococcus thermophilus DSM 20167T showed autolytic behavior when cultured in lactose- and sucrose-limited conditions. The amount of cell lysis induced was inversely related to the energetic status of the cells, as demonstrated by exposing cells to membrane-uncoupling and glycolysis inhibitors.



全球贸易项目编号

货号GTIN
O2751-5G04061834227182
O2751-100G04061834227175
O2751-25G04061832948355