S6510
N-琥珀酰-Leu-Leu-Val-Tyr-7-氨基-4-甲基香豆素
≥90% (HPLC), Chymotrypsin substrate, powder
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关于此项目
经验公式（希尔记法）:
C40H53N5O10
化学文摘社编号:
分子量:
763.88
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
N-琥珀酰-Leu-Leu-Val-Tyr-7-氨基-4-甲基香豆素, ≥90% (HPLC)
Quality Level
assay
≥90% (HPLC)
form
powder
solubility
0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key
UVFAEQZFLBGVRM-UHFFFAOYSA-N
General description
用作胰凝乳蛋白酶样酶的荧光底物，例如组织蛋白酶B和钙蛋白酶，其与程序性细胞死亡有关。
Application
用N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素测定水稻Jurkat细胞裂解液6和粗细胞裂解液中蛋白酶体类糜蛋白酶活性。7
Biochem/physiol Actions
在存在胰凝乳蛋白酶样酶活性的情况下，荧光团，7-氨基-4-甲基香豆素是从N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素中释放的。所获得的荧光可作为酶活性的量度。6
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
O Ullrich et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(11), 6223-6228 (1999-05-26)
The 20S proteasome has been shown to be largely responsible for the degradation of oxidatively modified proteins in the cytoplasm. Nuclear proteins are also subject to oxidation, and the nucleus of mammalian cells contains proteasome. In human beings, tumor cells
S Glockzin et al.
The Journal of biological chemistry, 274(28), 19581-19586 (1999-07-03)
The ubiquitin/proteasome pathway mediates the degradation of many short-lived proteins that are critically involved in the regulation of cell proliferation and cell death, including the tumor suppressor protein p53. Accumulation of p53 and induction of apoptosis in RAW 264.7 macrophages
T Reinheckel et al.
Archives of biochemistry and biophysics, 377(1), 65-68 (2000-04-25)
The 20S proteasome and the 26S proteasome are major components of the cytosolic and nuclear proteasomal proteolytic systems. Since proteins are known to be highly susceptible targets for reactive oxygen species, the effect of H(2)O(2) treatment of K562 human hematopoietic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S6510-10MG | 04061833265147 |
| S6510-1MG | 04061836959449 |
| S6510-5MG | 04061836959456 |