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S9009

Sar-Pro-Arg p-nitroanilide dihydrochloride

Name: Sar-Pro-Arg p-nitroanilide dihydrochloride
Brand: SIGMA

thrombin substrate, ≥97% (HPLC), powder

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₀N₈O₅ · 2HCl

化学文摘社编号:

75241-23-5

分子量:

535.42

UNSPSC Code:

12352204

PubChem Substance ID:

24899823

NACRES:

NA.32

MDL number:

MFCD00058168

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属性

产品名称

Sar-Pro-Arg p-nitroanilide dihydrochloride, thrombin substrate

Quality Level

300

assay

≥97% (HPLC)

form

powder

solubility

water: 25 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

Cl.CNCC(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc(cc2)N(=O)=O

InChI

1S/C20H30N8O5.ClH/c1-23-12-17(29)27-11-3-5-16(27)19(31)26-15(4-2-10-24-20(21)22)18(30)25-13-6-8-14(9-7-13)28(32)33;/h6-9,15-16,23H,2-5,10-12H2,1H3,(H,25,30)(H,26,31)(H4,21,22,24);1H

InChI key

KMSNYOSWLIQVAN-UHFFFAOYSA-N

说明

General description

Chromogenic substrate for thrombin.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

牛血浆凝血酶

凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

A clinical evaluation of automated chromogenic tests as substitutes for conventional prothrombin time and activated partial thromboplastin time tests.

A Duncan et al.

Clinical chemistry, 31(6), 853-855 (1985-06-01)

Automated procedures involving a chromogenic substrate sensitive to thrombin-sarcosine-Pro-Arg p-nitroanilide were compared with conventional tests for prothrombin times and activated partial thromboplastin times (APTT) and with specific assays for factors V, VII, VIII, IX, X, XI, and XII. The reproducibility

Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro).

Usman Bacha et al.

Chemical biology & drug design, 72(1), 34-49 (2008-07-10)

Coronaviruses comprise a large group of RNA viruses with diverse host specificity. The emergence of highly pathogenic strains like the SARS coronavirus (SARS-CoV), and the discovery of two new coronaviruses, NL-63 and HKU1, corroborates the high rate of mutation and

全球贸易项目编号

货号	GTIN
S9009-10MG	04061832925493
S9009-25MG	04061832925509