S9571
Anti-SUMO 2 兔抗
~0.6 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-SMT3B, Anti-SMT3H2, Anti-Sentrin-2
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~15 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~0.6 mg/mL
technique(s)
indirect immunofluorescence: 10-20 μg/mL using HeLa cells, western blot: 0.5-1 μg/mL using nuclear extract of HeLa cells or cell extract of HEK293-T cells transfected with human SUMO-2
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SUMO2(6613)
mouse ... Sumo2(170930)
General description
Small ubiquitin-related modifier (SUMO-2) gene is mapped to human chromosome 17q25.1. Sumo-2 is related to SUMO-3 with a 86% sequence identity. It comprises a sumoylation motif at the residue lysine 11.
Immunogen
synthetic peptide corresponding to amino acids 80-93 located at the C-terminal of human SUMO-2, conjugated to KLH. This sequence is identical in many species including rat, mouse, pig, and bovine SUMO-2 and is identical in human SUMO-3.
Application
Anti-SUMO-2 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Anti-SUMO-2 recognizes human SUMO-2.
Small ubiquitin-related modifier (SUMO-2) is essential for the cellular defense in hyperthermic cytotoxicity. Along with SUMO-3, SUMO2 is essential for cell survival post-heat shock. SUMO-2 has the ability to exist as self-modified polymers. SUMO-2 and SUMO-3 negatively regulate interferon induction.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovien serum albumin and 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
含少量动物源组分生物产品
此项目有
John T Crowl et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6798-6803 (2018-06-13)
Detection of nucleic acids by innate immune sensors triggers the production of type I interferons (IFNs). While IFNs are essential for host defense against viral infection, dysregulated production of IFNs underlies numerous autoinflammatory diseases. We have found that the loss
Rajarshi Chakrabarti et al.
Biochemical and biophysical research communications, 439(2), 209-214 (2013-09-03)
Phosphatidylinositol 4 phosphate 5 kinase 1α (PIP5K) is mainly localized in the cytosol and plasma membrane. Studies have also indicated its prominent association with nuclear speckles. The exact nature of this nuclear pool of PIP5K is not clear. Using biochemical
Hong-Lin Su et al.
Gene, 296(1-2), 65-73 (2002-10-18)
The SUMO (small ubiquitin-like modifier) protein and ubiquitin have similar 3-D structure. Sumolyzation and ubiquitination exhibit similar biological processes for post-translational modification. However, unlike ubiquitination, which targets proteins for degradation, sumolyzation participates in a number of cellular processes such as
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S9571-200UL | 04061837897740 |
| S9571-25UL | 04061837897757 |