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T1952

Trichostatin A, Ready Made Solution

Name: Trichostatin A, Ready Made Solution
Brand: SIGMA

5 mM in DMSO, from Streptomyces sp.

别名:

TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺, 曲古抑菌素 A，预制溶液

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₂N₂O₃

化学文摘社编号:

58880-19-6

分子量:

302.37

UNSPSC Code:

12352202

NACRES:

NA.32

Form:

DMSO solution

Assay:

≥98% (HPLC)

Biological source:

Streptomyces sp.

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属性

Quality Level

200

biological source

Streptomyces sp.

assay

≥98% (HPLC)

form

DMSO solution

concentration

5 mM in DMSO

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi, neoplastics

mode of action

enzyme | inhibits

shipped in

dry ice

storage temp.

−20°C

SMILES string

N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+

InChI key

RTKIYFITIVXBLE-WKWSCTOISA-N

说明

General description

曲古抑菌素A是一种一级羟肟酸。

Application

曲古抑菌素A即用型溶液已用于：

作为组蛋白去乙酰化酶抑制剂，通过干细胞试验研究其对转录组变化的影响
抑制原代垂体细胞培养物中的I、II或III类组蛋白去乙酰化酶(HDAC)，用于研究内源性人生长激素基因(hGH)的胰岛素调节
处理细胞进行HDAC抑制实验

Biochem/physiol Actions

曲古抑菌素 A (Trichostatin A，TSA) 是一种 链霉菌 代谢产物，在纳摩尔浓度下特异性抑制哺乳动物组蛋白去乙酰化酶，引起哺乳动物细胞内高度乙酰化的组蛋白分子积累。因此，曲古抑菌素 A 可用作研究体内组蛋白乙酰化的工具。曲古抑菌素 A 诱导细胞分化、细胞周期阻滞、逆转转化细胞形态和凋亡，并能够调节转录。TSA 已被用于建立一种新的克隆技术，从而提高了小鼠克隆的成功率。

曲古抑菌素 A 是一种链霉菌代谢产物，特异性抑制哺乳动物组蛋白去乙酰化酶。

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

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全球贸易项目编号

货号	GTIN
T1952-200UL	04061837338465