T2036
脱铁转铁蛋白 人
powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)
别名:
人转铁蛋白, 铁传递蛋白
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.75
MDL number:
eCl@ss:
34058011
product line
BioReagent
Quality Level
assay
≥98% (agarose gel electrophoresis)
form
powder
mol wt
76-81 kDa
concentration
~25 mM
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative, endotoxin, tested
solubility
H2O: 50 mg/mL
cation traces
Fe: ≤0.005%
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... TF(7018)
General description
转铁蛋白主要在肝脏中合成，是血清中含量丰富的糖蛋白。转铁蛋白超家族成员具有相似的多肽折叠模式。转铁蛋白含有N端和C端铁结合同源结构域。这些结构域中的每一个都被分裂成两个子结构域，在子结构域间隙内具有铁和阴离子的结合位点。绑定间隙随着铁释放和铁绑定打开和关闭。脱铁转铁蛋白是一种无铁蛋白，在转铁蛋白与其受体分离后产生。此产物可以补充铁或用于结合培养基中存在的游离铁。
Application
脱铁转铁蛋白已用于：
- 培养人原代胰腺内皮细胞、Het1As（非肿瘤食管细胞）和永生化人结肠上皮细胞（HCEC-1CT）
- 培养α小鼠肝12（AML-12）（成熟肝细胞）细胞
- 作为晶体学前纯化的人脱铁转铁蛋白的来源
Biochem/physiol Actions
转铁蛋白负责将铁从吸收和储存的部位运送到组织细胞。它能维持生物体液中的铁含量。转铁蛋白的水平可以反映总铁结合能力（TIBC）。转铁蛋白为骨髓中红细胞的血红蛋白提供所需的铁元素。缺铁会导致转铁蛋白水平升高。怀孕和服用雌激素也会提高转铁蛋白的水平。慢性肝病、肾功能不全、营养不良和蛋白质丢失性肠病会减少转铁蛋白的合成。
Other Notes
非血红素铁转运蛋白。
Disclaimer
供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
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存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
高风险级别生物产品--人源产品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2036-1G | 04061837338809 |
| T2036-100MG | 04061837338793 |
| T2036-500MG | 04061837338816 |