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T2528

Terbutaline hemisulfate salt

Name: Terbutaline hemisulfate salt
Brand: SIGMA

β-adrenoceptor agonist

别名:

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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关于此项目

线性分子式:

C₁₂H₁₉NO₃ · 1/2H₂SO₄

化学文摘社编号:

23031-32-5

分子量:

274.32

NACRES:

NA.77

PubChem Substance ID:

24278729

UNSPSC Code:

12352200

EC Number:

245-386-3

MDL number:

MFCD00079584

Quality level:

100

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属性

产品名称

Terbutaline hemisulfate salt,

Quality Level

100

solubility

H₂O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

说明

Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat⁴. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs⁵.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor⁶.

Features and Benefits

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

pictograms

GHS08

signalword

Danger

hcodes

H361,H370

pcodes

P202 - P260 - P264 - P270 - P280 - P308 + P311

Hazard Classifications

Repr. 2 - STOT SE 1

target_organs

Cardio-vascular system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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A comparison between clenbuterol, salbutamol and terbutaline in relation to receptor binding and in vitro relaxation of equine tracheal muscle.

K Törneke et al.

Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)

Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of

Urine and serum concentrations of inhaled and oral terbutaline.

J Elers et al.

International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)

We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2

Addition of intravenous beta(2)-agonists to inhaled beta(2)-agonists for acute asthma.

Andrew H Travers et al.

The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)

Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma

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全球贸易项目编号

货号	GTIN
T2528-1G	04061837342288
T2528-5G	04061837342295