Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by

eNeuro (2017-08-23)

Christopher J Holler, Georgia Taylor, Qiudong Deng, Thomas Kukar

摘要

Homozygous or heterozygous mutations in the

材料

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Sigma-Aldrich

抗-GAPDH抗体，小鼠单克隆小鼠抗, clone GAPDH-71.1, purified from hybridoma cell culture

Sigma-Aldrich

抗-GRN 兔抗, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution