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Merck
CN

761605

BrettPhos Pd G3

98%, solid

别名:

[(2-二-环己基膦基-3,6-二甲氧基-2′,4′,6′-三异丙基-1,1′-联苯基)-2-(2′-氨基-1,1′-联苯基)]甲磺酸钯 (II) 甲磺酸酯

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关于此项目

经验公式(希尔记法):
C48H66NO5PPdS
化学文摘社编号:
分子量:
906.50
UNSPSC Code:
12352300
PubChem Substance ID:
NACRES:
NA.22
MDL number:
Assay:
98%
Form:
solid
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产品名称

BrettPhos Pd G3, 98%

Quality Level

product line

Buchwald precatalyst Generation 3

assay

98%

form

solid

feature

generation 3

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: catalyst
core: palladium
reaction type: Cross Couplings

mp

150-193 °C (decomposition)

functional group

amine

SMILES string

CS(=O)(O[Pd]c1c(c2c(N)cccc2)cccc1)=O.COc3c(P(C4CCCCC4)C5CCCCC5)c(c6c(C(C)C)cc(C(C)C)cc6C(C)C)c(OC)cc3

InChI

1S/C35H53O2P.C12H10N.CH4O3S.Pd/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h19-25,27-28H,9-18H2,1-8H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;;;+1/p-1

InChI key

PQYBJDCHLVJYSD-UHFFFAOYSA-M

General description

BrettPhos Pd G3是第三代(G3)Buchwald预催化剂。它具有空气、水分和热稳定性,可溶于多种常见有机溶剂。它在溶液中的使用寿命很长。BrettPhos Pd G3是Buchwald-Hartwig交叉偶联反应的优异试剂。其独有特征包括催化剂负载量低、反应时间短、有效形成催化物质以及精确控制配体:钯比率。

Application

BrettPhos Pd G3可用于单取代脲和1,2二卤代芳族体系之间的C-N偶联反应,生成苯并咪唑酮。
可用于合成下列化合物:
  • 与[(肉桂基)PdCl]2和AgOTf反应生成[Pd(肉桂基)(BrettPhos)]OTf。
  • 与[(巴豆基)PdCl]2和AgOTf反应生成[Pd(巴豆基)(BrettPhos)]OTf。
  • 与[(烯丙基)PdCl]2和AgOTf反应生成[Pd(烯丙基)(BrettPhos)]OTf。
  • 与[(烯丙基)PdCl]2反应生成Pd(烯丙基)(BrettPhos)Cl。
对于小规模和高通量用途,产品为ChemBeads(928321


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

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商品

G3和G4 Buchwald预催化剂是一类最新的空气、湿度和热稳定型交叉偶联复合物,可用于键形成以实现其多功能性和高反应性。

All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.

G3 and G4 Buchwald palladium precatalysts are the newest air, moisture, and thermally stable crossing-coupling complexes used in bond formation for their versatility and high reactivity.

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The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electron-rich, and highly tunable to provide catalyst systems with a diverse scope, high stability and reactivity. Furthermore, the new series of precatalysts are air-, moisture and thermally-stable and display good solubility in common organic solvents. The use of precatalysts ensures the efficient generation of the active catalytic species and allows one to accurately adjust the ligand:palladium ratio. The ligands, precatalysts and methodology developed in the Buchwald group are user friendly and have rendered previously difficult cross couplings reactions, much easier to achieve.


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全球贸易项目编号

货号GTIN
761605-10G04061832970646
761605-5G04061832918457
761605-1G04061832918440
761605-250MG04061832970653