SYNTHESIS MADE SYNPLE - Synple Automatic Synthesizer & Reagent Cartridges
As a leading supplier of reagents and tools for chemical synthesis, we are continuously expanding our portfolio of innovative products to enhance and facilitate your research. Now, we’ve partnered with Synple Chem to bring you the ingenious Synple 2: a fully automated organic chemical synthesis system that is digitized and pre-programmed to generate your research products for you. Say goodbye to manual reactions. Discover how the incredible speed and accuracy of Synple 2 can boost your lab’s productivity and accelerate your discovery.
Key Features
5 x More efficient
- Fully automated organic synthesis
- 5 minutes to set up
- Frees your time to focus on more important experiments
Accurate & convenient
- Optimized reaction, no risk of human error
- Compact size (W 26 cm, H 36 cm, D 49 cm)
- Fast and easy orders through our web shop
70% Cost savings
- Considerably more economical than manual chemical synthesis due to lower personnel and reagent costs
No special training
- Easy to use, requires no detailed chemistry knowledge
- Modular system for a range of reactions at the press of a button
Enhanced safety
- Fully enclosed reaction
- User never exposed to chemicals
- Complies with latest safety standards
90% Less waste
- Fully optimized reaction sequence
- Uses minimum reagents and solvents, greatly reducing chemical waste
Synthesis in 4 Simple Steps
The platform consists of the Synple 2 chemical synthesizer and a range of reagent cartridges for different reactions. Simply add your starting material and the appropriate reagent cartridge to the synthesizer and press a button. The product is automatically generated, isolated and purified with only minutes of hands-on time and is running autonomously by itself during the reaction – not hours as in manual synthesis.
1. Set Up Your Reaction
2. Start Synthesis
3. Let Synple Work
4. Collect Your Product
1. Scan the pre-filled reagent cartridge and insert it into the synthesizer, then add your starting material.
2. Simply press the START button on the synthesizer.
3. The synthesizer generates, isolates, and purifies your product in minutes.
4. Synple then performs an automated washing sequence to prepare for your next synthesis.
How Synple Works
The Synple 2 synthesizer: contains two syringe pumps, and two rotary valves, in addition to a sample holder, cartridge holder, an RFID chip scanner, and a touchscreen. During synthesis, reactions can occur in the cartridge itself, or in the reaction vial.
Synple cartridges: are offered for a variety of reactions. Each cartridge contains all the reagents required to generate, isolate, and purify your product, as well as an RFID chip which is encoded with the reaction method.
5-Minute setup: Scan the cartridge on the synthesizer to automatically load the appropriate reaction method. Although the provided methods are suitable for a broad range of starting materials, you may adjust certain parameters, such as temperature or reaction time. To initiate the reaction, insert the cartridge into the synthesizer, add your starting material, and press START.
Automatic synthesis: The starting material is prepared (e.g., dissolved), and the solution is then circulated between the vial and the first cartridge compartment for a pre-defined time. Next, it is circulated through a further number of compartments, depending on the reagents required for the reaction.
Automatic cleaning: After your product is generated, the synthesizer performs automated washing so it’s contamination-free and ready for your next synthesis.
Unparalleled speed: While manual chemical synthesis can take up to several hours to complete, Synple 2 just requires 5 to 10 minutes of the user’s time.
Ordering is Just as Simple
The Synple 2 automated synthesis platform perfectly complements our existing chemistry portfolio, so you have all the products and tools you need from one reliable source. Take advantage of our swift online ordering process, and experience how robotic chemical synthesis will keep your work flowing.
N-Heterocycle Formation (SnAP)
Reductive Amination
Protein Degrader Formation
Biotin Tags
Mitsunobu
Boc Protection
Boc Deprotection
Fluorination
N-heterocycle formation cartridges simplify the conversion of a broad range of structurally and electronically diverse aldehydes into N-heterocycles, such as morpholines, piperazines, oxazepanes, and diazepanes, as well as complex spiro and bicyclic structures. They contain all reagents and catalysts needed for imine formation, cyclization, and purification.
Reaction Process
Starting Material
N-Heterocycle Formation
Synple 2
N-Heterocycle Scale: 0-0.5 mmol
Ordering Information
Reaction Process
Start: Aldehyde/Ketone
Reductive Amination
Synple 2
Product: Amine Scale: 0-0.5 mmol
Ordering Information
Protein degrader formation cartridges are designed for PROTAC® synthesis, and are available with either VHL or CRBN ligands in a variety of PEG linker lengths. They contain all reagents needed for linking the aldehyde or ketone group of the protein binder with the protein degrader building block, as well as for purification of the final product.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
Reaction Process
Starting Material
Protein Degrader Formation
Synple 2
Degrader Scale: 0-0.1 mmol
Ordering Information
For Amine Linker
For Amide Linker
Biotin tag cartridges allow attachment of a range of Biotin tags to either aldehydes and ketones through a reductive amination or amines via acylation. These cartridges are offered with various lengths of PEG linkers. They contain all reagents needed for tagging the compound, as well as for its purification.
Reaction Process
Start: Aldehyde/Ketone or Amine
Biotin Tags
Synple 2
Biotin Product Scale: 0-0.1 mmol
Ordering Information
The Mitsunobu cartridge allows automated reactions to form carbon-carbon bonds through dehydrative coupling of a primary or secondary alcohol with a range of pronucleophiles, such as phenols, phthalimides, tosylamides, and tosylhydrazones. Unlike manual synthesis, there is no risk of by-product formation, thus PPh3O removal is not required.
Reaction Process
Start: Alcohol
Mitsunobu
Synple 2
Product Scale: 0-0.5 mmol
Ordering Information
Reaction Process
Starting Material: Amine
Boc Protection
Synple 2
Boc-Amine Scale: 0-1.2 mmol
Ordering Information
Reaction Process
Boc-Amine
Boc Deprotection
Synple 2
Free Amine Scale: 0-0.5 mmol
Ordering Information
The fluorination (deoxyfluorination) cartridge is optimized for the transformation of primary and secondary alcohols into the corresponding fluorinated product. It enables fast and easy reactions, without exposing users to fluorinating agents as in manual synthesis. It is particularly beneficial for use in pharmaceutical chemistry, especially in late-stage functionalization.
Reaction Process
Starting Material: Alcohol
Fluorination
Synple 2
Product Scale: 0-0.5 mmol
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