A2221
Antithrombin III from human plasma
lyophilized powder, ≥95% (SDS-PAGE)
Synonym(s):
Factor Xa inhibitor, Heparin cofactor
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About This Item
biological source
human plasma
Quality Level
assay
≥95% (SDS-PAGE)
form
lyophilized powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SERPINC1(462)
Biochem/physiol Actions
Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase.
Physical form
Lyophilized from 20 mM Tris, pH 8.0
Other Notes
Not to be confused with thrombin antiserum.
One unit will form a complex and inhibit one unit of bovine thrombin at 25 degree C, using a 5 minute incubation in the presence of heparin.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Protocols
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine.
Alejandro Gugliucci
Life sciences, 82(7-8), 413-418 (2008-01-22)
Conditions in which serum or tissue acrolein levels are high (e.g.: renal failure, heavy smoking, oxidative stress) are also associated with increased thrombogenicity. Another emerging cardiovascular risk factor is homocysteine, and its derivative, homocysteine thiolactone. Antithrombin is one of the
Yu-Fang Hsieh et al.
Biomedical materials (Bristol, England), 12(6), 065004-065004 (2017-10-06)
Biodegradable polymers have potential as a scaffold material for making small diameter artery bypass grafts. To resist thrombosis, maintain biocompatibility and enhance the remodeling of the grafts, it is crucial to modify polymer scaffolds so that the grafts have antithrombogenic
Xiaopeng Tang et al.
Cell research, 30(2), 119-132 (2019-12-08)
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the concentrations of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting the existence of other coordinators.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2221-125UG | 04061833349823 |
| A2221-25UG | 04061833349830 |