412422
PAMAM dendrimer, ethylenediamine core, generation 3.0 solution
20 wt. % in methanol
Synonym(s):
Starburst PAMAM-G 3
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About This Item
Linear Formula:
[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32
CAS Number:
Molecular Weight:
6908.84
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
description
amino surface groups
Quality Level
form
liquid
mol wt
generation 3.0
feature
core type ethylenediamine core (2-carbon core)
concentration
20 wt. % in methanol
no. Surface Groups
32
refractive index
n20/D 1.367
bp
64.7 °C
density
0.863 g/mL at 25 °C
storage temp.
2-8°C
General description
PAMAM dendrimer is a symmetrical polymer with a large number of terminal groups that can easily bind to biomolecules due to their biocompatibility and affinity. These dendrimers have a multivalent surface that contains envelopes and various active sites at the core with the attached dendrons. They are highly branched nanoscale polymers that are extensively used in the field of biomedicine for targeted drug delivery.
Application
PAMAM dendrimers can be used as transfection agents for the delivery of nucleic acids. For example, it can be used in the pulmonary delivery of siRNA directed against tumor necrosis factor (TNF).
Physical form
Contains 32 surface primary amino groups
Legal Information
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
Regulatory Information
危险化学品
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Articles
Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.
Polyamidoamine dendrimers: Favorable polymeric nanomaterials for lipase activation
Amal A.M. Elgharbawy, et al.
Materials Today Communications, 25, 101492-101492 (2020)
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-? siRNA with PAMAM dendrimers in a murine model
Adam Bohr, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 156, 114-120 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 412422-1G | 04061837697036 |
| 412422-25G | 04061837697043 |
| 412422-2G | 04061837697050 |
| 412422-5G | 04061837697067 |