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457620

Polyglycolide

Name: Polyglycolide
Brand: ALDRICH

inherent viscosity 1.4dL/g

Synonym(s):

PGA, Poly(glycolic acid)

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About This Item

Linear Formula:

(C₂H₄O₃)_n

CAS Number:

26124-68-5

NACRES:

NA.23

PubChem Substance ID:

24869373

UNSPSC Code:

12162002

MDL number:

MFCD00148011

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Properties

Quality Level

100

form

solid

degradation timeframe

6-12 months

inherent viscosity

1.1-1.7 dL/g, 0.1 % (w/v) in hexafluoroisopropanol(25 °C)

transition temp

T_m 220-230 °C

solubility

hexafluoroisopropanol: soluble

density

1.53 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

OCC(O)=O

InChI

1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

InChI key

AEMRFAOFKBGASW-UHFFFAOYSA-N

Description

General description

Biodegradable and biocompatible PGA could be potentially useful for bone regeneration. High molecular weight polyglycolide (PGA) can be prepared by ring opening polymerization of diglycolide in the presence of diphenyl bismuth bromide.

Biodegradable polymer

Application

Polyglycolide (PGA) along with polylactide may be used to prepare a biodegradable copolymer to be used as implantations. Fabrication of biopolymer/carbon nanotube composite has been reported using PGA fiber as one of the constituents of the composite. Modified porous PGA scaffolds has been fabricated.

medical device

Preparation Note

To achieve solubility in hexafluoroisopropanol, melt crystalline product and quench with liquid nitrogen to change material to amorphous form.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

Effect of dsDNA wrapped single-walled carbon nanotubes on the thermal and mechanical properties of polycaprolactone and polyglycolide fiber blend composites

Spearman SS

Polymer, 56(15), 476-481 (2015)

Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA)

Hollinger JO

Journal of Biomedical Materials Research Part A, 17(1) (1983)

Diopside modified porous polyglycolide scaffolds with improved properties

Feng P, et al.

Royal Society of Chemistry Advances, 5, 54822-54829 (2015)

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Global Trade Item Number

SKU	GTIN
457620-10G	04061838140302
457620-1G	04061832342306
457620-5G	04061838140319