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About This Item
Empirical Formula (Hill Notation):
C73H140Na2O17P2
CAS Number:
Molecular Weight:
1397.81
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (710333P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.
Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized by de novo pathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2).
The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol.
Application
16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.
Biochem/physiol Actions
Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.
Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis.
Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.
Packaging
5 mL Amber Glass Screw Cap Vial (710333P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
755.6 - 820.4 °F
flash_point_c
402 - 438 °C
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The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015 (2015)
Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity
Balasubramanian K, et al.
Science Signaling, 8(395), 307-322 (2000)
Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast
Beranek A, et al.
The Journal of biological chemistry, 284(17), 11572-11578 (2009)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 710333P-25MG | 04061835228225 |