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Merck
CN

860355P

Avanti

16:0 PC-d62

Avanti Research - A Croda Brand

Synonym(s):

1,2-dipalmitoyl-d62-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C40H18NO8PD62
CAS Number:
Molecular Weight:
796.42
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
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Product Name

16:0 PC-d62, Avanti Research - A Croda Brand 860355P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (860355P-10mg), pkg of 1 × 100 mg (860355P-100mg), pkg of 1 × 200 mg (860355P-200mg), pkg of 1 × 25 mg (860355P-25mg)

manufacturer/tradename

Avanti Research - A Croda Brand 860355P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)COC(C([2H])([2H

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1/i1D3,2D3,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2,18D2,19D2,20D2,21D2,22D2,23D2,24D2,25D2,26D2,27D2,28D2,29D2,30D2,31D2,32D2,33D2

InChI key

KILNVBDSWZSGLL-PWXLRKPBSA-N

General description

16:0 PC-d62 is a deuterated phosphocholine (PC) in which 62 protons of dipalmitoyl are replaced by deuterium.
Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

Application

16:0 PC-d62 may be used for the preparation of asymmetric large unilamellar vesicles (aLUVs) for use as cell membrane models.

Packaging

5 mL Amber Glass Screw Cap Vial (860355P-100mg)
5 mL Amber Glass Screw Cap Vial (860355P-10mg)
5 mL Amber Glass Screw Cap Vial (860355P-200mg)
5 mL Amber Glass Screw Cap Vial (860355P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


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Storage Class

11 - Combustible Solids

Regulatory Information

美国出口管控产品

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Articles

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn


Preparation of asymmetric phospholipid vesicles for use as cell membrane models
Doktorova M, et al.
Nature Protocols, 13(9), 2086-2101 (2018)
Kalliopi-Kelli A Vandera et al.
Molecular pharmaceutics, 17(7), 2354-2369 (2020-05-01)
Gram-negative bacteria possess numerous defenses against antibiotics, due to the intrinsic permeability barrier of their outer membrane (OM), explaining the recalcitrance of some common and life-threatening infections. We report the formulation of a new drug, PPA148, which shows promising activity
Drew Marquardt et al.
Langmuir : the ACS journal of surfaces and colloids, 33(15), 3731-3741 (2017-01-21)
We measured the transbilayer diffusion of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in large unilamellar vesicles, in both the gel (Lβ') and fluid (Lα) phases. The choline resonance of headgroup-protiated DPPC exchanged into the outer leaflet of headgroup-deuterated DPPC-d13 vesicles was monitored using 1H



Global Trade Item Number

SKUGTIN
860355P-100MG04061835186358
860355P-10MG04061835186365
860355P-200MG04061835186372
860355P-25MG04061835186389