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About This Item
Empirical Formula (Hill Notation):
C24H47NO7
CAS Number:
Molecular Weight:
461.63
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
Galactosyl(β) Sphingosine (d18:1), Avanti Research™ - A Croda Brand 860537P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (860537P-25mg), pkg of 1 × 5 mg (860537P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860537P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChI
1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
InChI key
HHJTWTPUPVQKNA-PIIMIWFASA-N
General description
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.
Application
Galactosyl(β) Sphingosine (d18:1) has been used in the liposome preparation for α-synuclein aggregation studies. It is suitable for use to test its inhibitory effect on cytokinesis in cells expressing T-cell death-associated gene 8 (TDAG8). It is also suitable for use as a standard for differential mobility spectrometry (DMS) coupled with liquid chromatography in electrospray ionizatoin tandem mass spectrometry (LC-ESI-DMS-MS/MS) for ceramide quantification and ultra-high resolution ion mobility spectrometry measurments.
Biochem/physiol Actions
Galatosylsphingosine or psychosine is a cytotoxic lipid which accumulates in oligodendrocytes due to dysfunctional lysosomal enzyme galactosylceramidase and is implicated in globoid cell leukodystrophy. Psychosine accumulation induces demyelination, astrocyte dysfunction and pro-inflammatory cytokine release in Krabbe disease.
Packaging
5 mL Amber Glass Screw Cap Vial (860537P-25mg)
5 mL Amber Glass Screw Cap Vial (860537P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling
OSullivan C and Dev KK
Journal of Cell Science, 128(21), 3878-3887 (2015)
Comprehensive profiling of glycosphingolipid glycans using a novel broad specificity endoglycoceramidase in a high-throughput workflow
Albrecht S, et al.
Analytical Chemistry, 88(9), 4795-4802 (2016)
Lipid and glycolipid isomer analyses using ultra-high resolution ion mobility spectrometry separations
Wojcik R, et al.
International Journal of Molecular Sciences, 18(1), 183-183 (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 860537P-25MG | 04061835317912 |
| 860537P-5MG | 04061835317929 |