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860569P

Avanti

C17 Glucosyl(β) Ceramide (d18:1/17:0)

Avanti Research™ - A Croda Brand

Synonym(s):

D-glucosyl-β-1,1′-N-heptadecanoyl-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C41H79NO8
CAS Number:
1252807-00-3
Molecular Weight:
714.07
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

C17 Glucosyl(β) Ceramide (d18:1/17:0), Avanti Research™ - A Croda Brand 860569P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (860569P-25mg), pkg of 1 × 5 mg (860569P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860569P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

InChI

1S/C41H79NO8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-37(45)42-34(33-49-41-40(48)39(47)38(46)36(32-43)50-41)35(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h28,30,34-36,38-41,43-44,46-48H,3-27,29,31-33H2,1-2H3,(H,42,45)/b30-28+/t34-,35+,36+,38+,39-,40+,

InChI key

VQADGGHNXABKOV-VIBFQTAGSA-N

General description

Glucosyl(β) Ceramide (β-GlcCer) is a naturally occurring glycolipid. It is also a ubiquitous intracellular metabolite.

Biochem/physiol Actions

Glucosyl(β) Ceramide (β-GlcCer) regulates the activity of natural killer T (NKT) lymphocytes and displays antimetastatic effects. It is an endogenous macrophage inducible C-type lectin (Mincle) ligand, which exhibits immunostimulatory property. β-GlcCer promotes inflammatory and acquired immune responses on myeloid cells via Mincle. It acts as a potential biomarker for Gaucher′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (860569P-25mg)
5 mL Amber Glass Screw Cap Vial (860569P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Regulatory Information

涉药品监管产品

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Masashi Inafuku et al.
Lipids, 47(6), 581-591 (2012-03-20)
Natural killer (NK) T cells are well known to play important roles in both tumor rejection and the defense against infectious. Therefore, the antitumor potential of NKT cell-activating antigens have been the focus for the development of NKT cell-based immunotherapies.
E Zigmond et al.
Gut, 56(1), 82-89 (2006-12-19)
beta-Glucosylceramide, a naturally occurring glycolipid, exerts modulatory effects on natural killer T (NKT) lymphocytes. To determine whether beta-glucosylceramide can alter NKT function in opposite directions, colitis was induced by intracolonic installation of trinitrobenzenesulphonic acid, and hepatocellular carcinoma (HCC) was induced

Global Trade Item Number

SKUGTIN
860569P-25MG04061835318131
860569P-5MG04061835318148