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1.02994

Sorbitol

liquid, (sorbitol syrup, crystallizing), EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, USP, E 420

Synonym(s):

D-Sorbitol, Karion, D-Glucitol

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
50-70-4
Molecular Weight:
182.17
E Number:
E420
UNSPSC Code:
12352201
Beilstein/REAXYS Number:
1721899
MDL number:
MFCD00004708
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Quality Level

500

agency

BP, ChP, Ph. Eur., USP

vapor density

<1 (vs air)

vapor pressure

<0.1 mmHg ( 25 °C)

product line

EMPROVE® ESSENTIAL

form

liquid, viscous liquid

pH

6 (20 °C in H2O, 50% solution)

mp

98-100 °C (lit.)

density

1.3 g/cm3

application(s)

liquid formulation
pharmaceutical

storage temp.

15-25°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

General description

Whether suspensions, emulsions or solutions – oral liquid dosage forms offer a number of advantages: They allow for individual dosing, are easy to swallow and are suitable for pediatric or geriatric applications. On the other hand, formulators face considerable challenges concerning solubility, API stability in aqueous systems, or taste that can often make a decisive difference. Our large product portfolio covers all excipients required for oral liquid formulation, as solvents and surfactants, flavors, ph adjustments and buffers, preservatives and viscosity enhancers.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sorbitol is a sugar alcohol which is frequently used as sweetener in oral liquid pharmaceutical formulations, as well as bulking agent, sugar substitute or humectant in cosmetics and food and beverage.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

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Articles

Strategies for the Development of Safe and Effective Pediatric Formulations

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.

Related Content

Pediatric Formulations

Developing formulations specifically for infants and children is increasingly important. To help you master these challenges effectively, we offer an extensive portfolio of well-established high-quality excipients and APIs for pediatric pharmaceutical formulations that are proven in practice.

Global Trade Item Number

SKUGTIN
102994905004022536038681
102994927004022536038698