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Merck
CN

1.06346

Sodium dihydrogen phosphate monohydrate

for analysis EMSURE® ACS,Reag. Ph Eur

Synonym(s):

Sodium phosphate monobasic monohydrate, Monosodium phosphate, Sodium dihydrogen phosphate monohydrate

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About This Item

Linear Formula:
NaH2PO4 · H2O
CAS Number:
Molecular Weight:
137.99
NACRES:
NA.21
EC Index Number:
231-449-2
UNSPSC Code:
12352302
MDL number:
Assay:
99.0-102.0% (alkalimetric)
Grade:
ACS reagent
Form:
crystals
Solubility:
850 g/L
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Quality Level

grade

ACS reagent

agency

reag. Ph. Eur.

product line

EMSURE®

assay

99.0-102.0% (alkalimetric)

form

crystals

potency

>2000 mg/kg LD50, oral (Rat), >7940 mg/kg LD50, skin (Rabbit)

impurities

≤0.01% Insoluble matter

pH

4.1-4.5 (25 °C, 50 g/L in H2O)

solubility

850 g/L

density

2.04 g/cm3 at 20 °C

bulk density

880 kg/m3

anion traces

chloride (Cl-): ≤0.0005%, sulfate (SO42-): ≤0.003%

cation traces

Ca: ≤0.005%, Fe: ≤0.0005%, K: ≤0.005%, N: ≤0.001%, heavy metals: ≤0.0005%

UV absorption

λ: 280 nm Amax: ≤0.05

storage temp.

2-30°C

SMILES string

[Na+].[H]O[H].OP(O)([O-])=O

InChI

1S/Na.H3O4P.H2O/c;1-5(2,3)4;/h;(H3,1,2,3,4);1H2/q+1;;/p-1

InChI key

BBMHARZCALWXSL-UHFFFAOYSA-M

Application


  • Development of a multiparticulate drug delivery system for in situ amorphisation.: This study explores the use of sodium dihydrogen phosphate monohydrate in developing a multiparticulate drug delivery system. The research highlights the compound′s role in achieving in situ amorphisation, enhancing drug solubility and bioavailability (Holm TP et al., 2022).

  • Metabolomic characterization of rhubarb species by capillary electrophoresis and ultra-high-pressure liquid chromatography.: Sodium dihydrogen phosphate monohydrate is utilized in the buffer system for capillary electrophoresis and UHPLC, aiding in the metabolomic analysis of rhubarb species. This research underscores its importance in improving separation efficiency and resolution in analytical methods (Tseng YJ et al., 2013).

Analysis Note

Assay (alkalimetric): 99.0 - 102.0 %
Insoluble matter: ≤ 0.01 %
pH-value (5 %; water, 25 °C): 4.1 - 4.5
UV absorption (280 nm; 1 mol/l; 1 cm; water): ≤ 0.05
Chloride (Cl): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.003 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (ACS): ≤ 0.0005 %
Ca (Calcium): ≤ 0.005 %
Fe (Iron): ≤ 0.0005 %
K (Potassium): ≤ 0.005 %
Corresponds to ACS,Reag. Ph Eur

Other Notes

Replaces: SX0709; SX0709-5; SX0710; SX0710-1; SX0710-3; SX0710-5; SX0710-20

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
106346050004022536075334
106346902504022536075372
106346100004022536075358
106346901204027269691530
106346905004022536075389